Business as usual is a dead-end pathway to recurring crises and collapse of vital life-support systems. The pressure to transform mounts as the 2030 Agenda deadline approaches and as the world takes stock of the causes and consequences of the COVID-19 pandemic. The potential and appetite for transformation may never be this great again. We now have an unprecedented window of opportunity to advance the agenda and the impact of research on transformations to sustainability. But that research remains fragmented and, in many ways, contested. We work with different understandings and definitions of transformation; we fail to integrate the wealth of existing knowledge about past processes of social change and transition. We need to confront remaining gaps in our understanding on how transformations can be catalysed, steered in ways that are socio-politically feasible and desirable, and scaled up towards achieving global sustainability. This Collection of Global Sustainability aims to bring together theoretical and practical knowledge from systematic research in transformations towards sustainability. We welcome contributions in areas such as: